Location and Contact Information
Research in the Salvatore lab is focused primarily on pulmonary fibrosis, studying the patterns of fibrosis and the rate of change on chest CT over time. We are developing a radiologic tool to differentiate the most common types of fibrosis on imaging to assist in making the best multidisciplinary diagnosis. We have described a visual change in bronchial angles that is associated with nonspecific interstitial pneumonitis pattern on CT, and we are working to provide a computer analysis of the bronchial angles to facilitate the correct diagnosis. Currently, we are investigating how lung cancer in fibrosis is different than lung cancer occurring in emphysema, which may require modification of screening techniques to diagnose early cancer. We are incorporating artificial intelligence tools to analyze not only the radiology but also the pathology.
Concurrently we are investigating fibrosis across organ systems and its overlap. Breast stroma composed of collagen contributes to breast density on mammography and is associated with increased risk for breast cancer. We will take what we have learned about lung fibrosis on chest CT and apply to breast density on chest CT and its relationship with breast cancer.
Salvatore M, Henschke CI, Yip R, Jacobi A, Eber C, Padilla M, Knoll A, Yankelevitz D. JOURNAL CLUB: Evidence of Interstitial Lung Disease on Low-Dose Chest CT Images: Prevalence, Patterns, and Progression. AJR Am J Roentgenol. 2016 Mar;206(3):487-94. doi: 10.2214/AJR.15.15537. Epub 2015 Dec 23. PMID: 26700157.
Capaccione KM, Wang A, Lee SM, Patel N, Austin JHM, Maino P, Padilla M, Salvatore MM. Quantifying normal lung in pulmonary fibrosis: CT analysis and correlation with %DLCO. Clin Imaging. 2021 Sep;77:287-290. doi: 10.1016/j.clinimag.2021.06.021. Epub 2021 Jun 18. PMID: 34171742.
Salvatore M, Ishikawa G, Padilla M. Is It Idiopathic Pulmonary Fibrosis or Not? J Am Board Fam Med. 2018 Jan-Feb;31(1):151-162. doi: 10.3122/jabfm.2018.01.170288. PMID: 29330249.
Salvatore M, Smith ML. Cross sectional imaging of pulmonary fibrosis translating pathology into radiology. Clin Imaging. 2018 Sep-Oct;51:332-336. doi: 10.1016/j.clinimag.2018.06.013. Epub 2018 Jun 27. PMID: 29960266.
Snijder J, Peraza J, Padilla M, Capaccione K, Salvatore MM. Pulmonary fibrosis: a disease of alveolar collapse and collagen deposition. Expert Rev Respir Med. 2019 Jul;13(7):615-619. doi: 10.1080/17476348.2019.1623028. Epub 2019 Jun 5. PMID: 31117843.
Salvatore M, Singh A, Yip R, Fevrier E, Henschke CI, Yankelevitz D, Padilla M. Progression of probable UIP and UIP on HRCT. Clin Imaging. 2019 Nov-Dec;58:140-144. doi: 10.1016/j.clinimag.2019.07.003. Epub 2019 Jul 12. PMID: 31326632.
Whittaker Brown SA, Padilla M, Mhango G, Powell C, Salvatore M, Henschke C, Yankelevitz D, Sigel K, de-Torres JP, Wisnivesky J. Interstitial Lung Abnormalities and Lung Cancer Risk in the National Lung Screening Trial. Chest. 2019 Dec;156(6):1195-1203. doi: 10.1016/j.chest.2019.06.041. Epub 2019 Aug 9. PMID: 31404527.
Kim JS, Anderson MR, Bernstein EJ, Oelsner EC, Raghu G, Noth I, Tsai MY, Salvatore M, Austin JHM, Hoffman EA, Barr RG, Podolanczuk AJ. Associations of D-Dimer with Computed Tomographic Lung Abnormalities, Serum Biomarkers of Lung Injury, and Forced Vital Capacity: MESA Lung Study. Ann Am Thorac Soc. 2021 Nov;18(11):1839-1848. doi: 10.1513/AnnalsATS.202012-1557OC. PMID: 33861685.
Capaccione KM, Austin JHM, Saqi A, Patel N, Padilla M, Salvatore MM. Hypersensitivity pneumonitis: Airway-centered pulmonary fibrosis on chest CT. Respir Investig. 2021 Nov;59(6):845-848. doi: 10.1016/j.resinv.2021.06.011. Epub 2021 Aug 6. PMID: 34373236.
Salvatore M, Toussie D, Pavlishyn N, Yankelevitz D, O'Connor T, Henschke C, Padilla M. The right upper lobe bronchus angle: A tool for differentiating fibrotic and non-fibrotic sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2020;37(2):99-103. doi: 10.36141/svdld.v37i2.8965. Epub 2020 Jun 30. PMID: 33093775; PMCID: PMC7569551.