Diffusion-weighted image shows parallel distal femoral tracts in the physis and proximal metaphysis of a 3-week-old piglet. The direction of the columns of the physis and metaphysis mirrors that of the histologic section at right. (Radiology, 2003)
13-year-old healthy girl who grew 4 cm during previous year. Coronal (a) and sagittal (b) tractographic images show tracts in the femur & tibia with femoral tracts being more prominent. Sagittal (c) gradient echo images show that physes are open but thin.
Sagittal tractography on a 12-year-old boy. Reconstructed physis is shown in blue. Parallel red tracts extend from the physis to the metaphysis.
Sagittal tractography on a 12-year-old boy, viewed from above. Tracts (red and orange) extend from the physis to the metaphysis.
Funding: NIH 1 R01 HD104720-01 (2021-2026) and Society for Pediatric Radiology Research and Education Fund (2020-2022)
Principal Investigator: Diego Jaramillo, MD, MPH
Summary: We measure height velocity during early puberty and serial changes in physeal DTI tract volume in children imaged at 0, 4, 8, and 12 months and then annually during the four years of the growth spurt.
Simukayi Mutasa, MD, Sachin Jambawalikar, PhD, Diego Jaramillo, MD
Summary: We have performed a study to compare manual segmentation by several observers with automated segmentation performed using a 3D U-net network. Our hypothesis is that the automated segmentation can provide comparable results to the manual process with a significant gain in time.