Laurent Dercle, MD, PhD

Overview
Dr. Laurent Dercle, MD, PhD, is an associate research scientist in the Department of Radiology at Columbia University Irving Medical Center. Dr. Dercle earned his medical degree at Paris XI University. He obtained board certification in nuclear medicine after completing a residency in Toulouse University Hospital. He specialized in cancer imaging at Gustave Roussy Cancer Campus Grand Paris, where he was an assistant attending. He completed a PhD in oncology on artificial intelligence-driven extraction of information from medical images to guide clinical decision making in cancer patients treated with immunotherapy.
Since joining the Department of Radiology in 2016, Dr. Dercle’s research has been focused on applying artificial intelligence to improve the care of cancer patients. He published several papers on novel imaging biomarkers to predict tumor sensitivity to systemic therapies, guide cancer treatment decisions, and improve patients’ survival.
Academic Appointments
- Associate Research Scientist in the Department of Radiology
Gender
- Male
Credentials & Experience
Education & Training
- MD, University of Paris-Saclay
- MS, Physics and signal processing, University of Toulouse
- PhD, Gustave Roussy, University of Paris-Saclay
Honors & Awards
2019 Radiology Editor’s Recognition Award: reviewing with distinction, Radiological Society of North America
2018 Fellow Research Prize, Radiological Society of North America
2018 PEPS Award, French Ministry of Higher Education, Research and Innovation
2018 French Tech Innovation Grant, French Public Investment Bank
2017 Fellow Research Prize, Radiological Society of North America
2017 Research grant, Nuovo-Soldadi Foundation
2016 Research grant, ARC Foundation
2015 Course of Excellence in Oncology, Philanthropia Foundation
2015 Travel Award for Young Investigators in Molecular Imaging, Radiological Society of North America
2015 Gold Medal Award, Toulouse University
Research
Dr. Dercle’s translational research focuses on how non-invasive quantitative imaging biomarkers can be used to guide treatment decision and improve patients’ outcome. He studies precision medicine approaches driven by artificial intelligence in the fields of oncology, immunotherapy, and cancer imaging. He is conducting research on the applications of machine-learning and radiomics in the Computational Image Analysis Laboratory, including evaluation of how spatial and temporal changes in tumor imaging phenotypes can provide early prediction of tumor sensitivity to systemic therapies, guide treatment decisions, and forecast survival.
Selected Publications
- Dercle, L., Fronheiser, M., Lu, L., Du, S., Hayes, W., Leung, D.K., Roy, A., Wilkerson, J., Guo, P., Fojo, A.T., Schwartz, L.H., & Zhao B. (2020). Identification of Non-Small Cell Lung Cancer Sensitive to Systemic Cancer Therapies Using Radiomics.Clinical Cancer Research
- Dercle, L., Lu, L., Schwartz, L. H., Qian, M., Tejpar, S., Eggleton, P., Zhao, B., & Piessevaux, H. (2020). Radiomics Response Signature for Identification of Metastatic Colorectal Cancer Sensitive to Therapies Targeting EGFR Pathway. Journal of the National Cancer Institute
- Yeh, R., Trager, M. H., Rizk, E. M., Finkel, G. G., Barker, L. W., Carvajal, R. D., Geskin, L. J., Schwartz, G. K., Schwartz, L., Dercle, L., & Saenger, Y. M. (2020). FLT-PET At 6 Weeks Predicts Response Assessed by CT at 12 Weeks in Melanoma Patients Treated With Pembrolizumab. Clinical nuclear medicine
- Seban, R. D., Schwartz, L. H., Bonardel, G., & Dercle, L. (2020). Diagnosis of Hyper-progressive Disease in Patients Treated with Checkpoint Inhibitors using 18F-FDG PET/CT. Journal of nuclear medicine
- Dercle, L., Ma, J., Xie, C., Chen, A. P., Wang, D., Luk, L., Revel-Mouroz, P., Otal, P., Peron, J. M., Rousseau, H., Lu, L., Schwartz, L. H., Mokrane, F. Z., & Zhao, B. (2020). Using a single abdominal computed tomography image to differentiate five contrast-enhancement phases: A machine-learning algorithm for radiomics-based precision medicine. European journal of radiology
- Manson, G., Brice, P., Herbaux, C., Bouabdallah, K., Antier, C., Poizeau, F., Dercle, L., & Houot, R. (2020). Efficacy of anti-PD1 re-treatment in patients with Hodgkin lymphoma who relapsed after anti-PD1 discontinuation. Haematologica
- Tselikas, L., Sun, R., Ammari, S., Dercle, L., Yevich, S., Hollebecque, A., Ngo-Camus, M., Nicotra, C., Deutsch, E., Deschamps, F., & de Baere, T. (2019). Role of image-guided biopsy and radiomics in the age of precision medicine. Chinese clinical oncology
- Rozenblum, L., Mokrane, F. Z., Yeh, R., Sinigaglia, M., Besson, F. L., Seban, R. D., Zadro, C., Dierickx, L., Chougnet, C. N., Partouche, E., Revel-Mouroz, P., Zhao, B., Otal, P., Schwartz, L. H., & Dercle, L. (2020). Imaging-guided precision medicine in non-resectable gastro-entero-pancreatic neuroendocrine tumors: A step-by-step approach. European journal of radiology
- Seban, R. D., Mezquita, L., Berenbaum, A., Dercle, L., Botticella, A., Le Pechoux, C., Caramella, C., Deutsch, E., Grimaldi, S., Adam, J., Ammari, S., Planchard, D., Leboulleux, S., & Besse, B. (2019). Baseline metabolic tumor burden on FDG PET/CT scans predicts outcome in advanced NSCLC patients treated with immune checkpoint inhibitors. European journal of nuclear medicine and molecular imaging
- Chen, A., Mokrane, F. Z., Schwartz, L., Morschhauser, F., Stamatoullas, A., Schiano de Colella, J. M., Vercellino, L., Casasnovas, O., Chauchet, A., Delmer, A., Nicolas-Virelizier, E., Ghesquières, H., Moles-Moreau, M. P., Schmitt, A., Dulery, R., Bouabdallah, K., Borel, C., Touati, M., Deau-Fischer, B., Peyrade, F., … Dercle, L. (2019). Early 18F-FDG PET/CT response predicts survival in Relapsed/Refractory Hodgkin Lymphoma treated with Nivolumab. Journal of nuclear medicine
- Mokrane, F. Z., Lu, L., Vavasseur, A., Otal, P., Peron, J. M., Luk, L., Yang, H., Ammari, S., Saenger, Y., Rousseau, H., Zhao, B., Schwartz, L. H., & Dercle, L. (2020). Radiomics machine-learning signature for diagnosis of hepatocellular carcinoma in cirrhotic patients with indeterminate liver nodules. European radiology
- Sinigaglia, M., Assi, T., Besson, F. L., Ammari, S., Edjlali, M., Feltus, W., Rozenblum-Beddok, L., Zhao, B., Schwartz, L. H., Mokrane, F. Z., & Dercle, L. (2019). Imaging-guided precision medicine in glioblastoma patients treated with immune checkpoint modulators: research trend and future directions in the field of imaging biomarkers and artificial intelligence. EJNMMI research
- Moya-Plana, A., Mangin, D., Dercle, L., Taouachi, R., Casiraghi, O., Ammari, S., Nguyen, F., Temam, S., Robert, C., & Gorphe, P. (2019). Risk-based stratification in head and neck mucosal melanoma. Oral oncology
- Mekki, A., Dercle, L., Lichtenstein, P., Nasser, G., Marabelle, A., Champiat, S., Chouzenoux, E., Balleyguier, C., & Ammari, S. (2019). Machine learning defined diagnostic criteria for differentiating pituitary metastasis from autoimmune hypophysitis in patients undergoing immune checkpoint blockade therapy. European journal of cancer
- Seban, R. D., Nemer, J. S., Marabelle, A., Yeh, R., Deutsch, E., Ammari, S., Moya-Plana, A., Mokrane, F. Z., Gartrell, R. D., Finkel, G., Barker, L., Bigorgne, A. E., Schwartz, L. H., Saenger, Y., Robert, C., & Dercle, L. (2019). Prognostic and theranostic 18F-FDG PET biomarkers for anti-PD1 immunotherapy in metastatic melanoma: association with outcome and transcriptomics. European journal of nuclear medicine and molecular imaging
- Moya-Plana, A., Herrera Gómez, R. G., Rossoni, C., Dercle, L., Ammari, S., Girault, I., Roy, S., Scoazec, J. Y., Vagner, S., Janot, F., Eggermont, A., & Robert, C. (2019). Evaluation of the efficacy of immunotherapy for non-resectable mucosal melanoma. Cancer immunology, immunotherapy
- Ma, J., Dercle, L., Lichtenstein, P., Wang, D., Chen, A., Zhu, J., Piessevaux, H., Zhao, J., Schwartz, L. H., Lu, L., & Zhao, B. (2020). Automated Identification of Optimal Portal Venous Phase Timing with Convolutional Neural Networks. Academic radiology
- Manson, G., Mear, J. B., Herbaux, C., Schiano, J. M., Casasnovas, O., Stamatoullas, A., Deau, B., Schmitt, A., Garnier, G., Regny, C., Bouabdallah, K., Moles-Moreau, M. P., Ghesquieres, H., Tempescul, A., Dulery, R., Nicolas-Virelizier, E., Delmer, A., Borel, C., Chauchet, A., Damotte, D., … LYSA (2019). Long-term efficacy of anti-PD1 therapy in Hodgkin lymphoma with and without allogenic stem cell transplantation. European journal of cancer
- Seban, R. D., Robert, C., Dercle, L., Yeh, R., Dunant, A., Reuze, S., Schernberg, A., Sun, R., Mignot, F., Terroir, M., Schlumberger, M., Haie-Meder, C., Chargari, C., & Deutsch, E. (2019). Increased bone marrow SUVmax on 18F-FDG PET is associated with higher pelvic treatment failure in patients with cervical cancer treated by chemoradiotherapy and brachytherapy. Oncoimmunology
- Rozenblum, L., Mokrane, F. Z., Yeh, R., Sinigaglia, M., Besson, F., Seban, R. D., Chougnet, C. N., Revel-Mouroz, P., Zhao, B., Otal, P., Schwartz, L. H., & Dercle, L. (2019). The role of multimodal imaging in guiding resectability and cytoreduction in pancreatic neuroendocrine tumors: focus on PET and MRI. Abdominal radiology
- Dercle, L., Mokrane, F. Z., Schiano de Colella, J. M., Stamatoullas, A., Morschhauser, F., Brice, P., Ghesquières, H., Casasnovas, O., Chen, A., Manson, G., & Houot, R. (2019). Unconventional immune-related phenomena observed using 18F-FDG PET/CT in Hodgkin lymphoma treated with anti PD-1 monoclonal antibodies. European journal of nuclear medicine and molecular imaging
- Yeh, R., Tay, Y. D., Tabacco, G., Dercle, L., Kuo, J. H., Bandeira, L., McManus, C., Leung, D. K., Lee, J. A., & Bilezikian, J. P. (2019). Diagnostic Performance of 4D CT and Sestamibi SPECT/CT in Localizing Parathyroid Adenomas in Primary Hyperparathyroidism. Radiology
- Dercle, L., Connors, D. E., Tang, Y., Adam, S. J., Gönen, M., Hilden, P., Karovic, S., Maitland, M., Moskowitz, C. S., Kelloff, G., Zhao, B., Oxnard, G. R., & Schwartz, L. H. (2018). Vol-PACT: A Foundation for the NIH Public-Private Partnership That Supports Sharing of Clinical Trial Data for the Development of Improved Imaging Biomarkers in Oncology. JCO clinical cancer informatics
- Li, Y., Lu, L., Xiao, M., Dercle, L., Huang, Y., Zhang, Z., Schwartz, L. H., Li, D., & Zhao, B. (2018). CT Slice Thickness and Convolution Kernel Affect Performance of a Radiomic Model for Predicting EGFR Status in Non-Small Cell Lung Cancer: A Preliminary Study. Scientific reports
- Dercle, L., Billey, C., Cognet, T., Cassol, E., Sinigaglia, M., Pascal, P., Berry, I., Otal, P., Bureau, C., & Lairez, O. (2018). Spleno-hepatic index to predict portal hypertension by equilibrium radionuclide ventriculography. Nuclear medicine communications
- Sun, R., Limkin, E. J., Vakalopoulou, M., Dercle, L., Champiat, S., Han, S. R., Verlingue, L., Brandao, D., Lancia, A., Ammari, S., Hollebecque, A., Scoazec, J. Y., Marabelle, A., Massard, C., Soria, J. C., Robert, C., Paragios, N., Deutsch, E., & Ferté, C. (2018). A radiomics approach to assess tumour-infiltrating CD8 cells and response to anti-PD-1 or anti-PD-L1 immunotherapy: an imaging biomarker, retrospective multicohort study. The Lancet. Oncology
- Reuzé, S., Schernberg, A., Orlhac, F., Sun, R., Chargari, C., Dercle, L., Deutsch, E., Buvat, I., & Robert, C. (2018). Radiomics in Nuclear Medicine Applied to Radiation Therapy: Methods, Pitfalls, and Challenges. International journal of radiation oncology, biology, physics
- Manson, G., Herbaux, C., Brice, P., Bouabdallah, K., Stamatoullas, A., Schiano, J. M., Ghesquieres, H., Dercle, L., Houot, R., & Lymphoma Study Association (2018). Prolonged remissions after anti-PD-1 discontinuation in patients with Hodgkin lymphoma. Blood
- Mekki, A., Dercle, L., Lichtenstein, P., Marabelle, A., Michot, J. M., Lambotte, O., Le Pavec, J., De Martin, E., Balleyguier, C., Champiat, S., & Ammari, S. (2018). Detection of immune-related adverse events by medical imaging in patients treated with anti-programmed cell death 1. European journal of cancer
- Colleter, R., Dedouit, F., Duchesne, S., Gérard, P., Dercle, L., Poilpré, P., Gendrot, V., Rousseau, H., Crubézy, É., Telmon, N., & Mokrane, F. Z. (2018). Study of a seventeenth-century French artificial mummy: autopsical, native, and contrast-injected CT investigations. International journal of legal medicine
- Pascal, P., Dercle, L., Weyts, K., Meyer, N., & Courbon, F. (2018). Complete Metabolic Response of Advanced Melanoma to Vemurafenib Assessed with FDG-PET-CT at 85 Hours. Clinical nuclear medicine
- Mokrane, F. Z., Dercle, L., Meyrignac, O., Crubézy, É., Rousseau, H., Telmon, N., & Dedouit, F. (2018). Towards multi-phase postmortem CT angiography in children: a study on a porcine model. International journal of legal medicine
- Dercle, L., Ammari, S., Seban, R. D., Schwartz, L. H., Houot, R., Labaied, N., Mokrane, F. Z., Lazarovici, J., Danu, A., Marabelle, A., Ribrag, V., & Michot, J. M. (2018). Kinetics and nadir of responses to immune checkpoint blockade by anti-PD1 in patients with classical Hodgkin lymphoma. European journal of cancer
- Turpin, A., Michot, J. M., Kempf, E., Mazeron, R., Dartigues, P., Terroir, M., Boros, A., Bonnetier, S., Castilla-Llorente, C., Coman, T., Danu, A., Ghez, D., Pilorge, S., Arfi-Rouche, J., Dercle, L., Soria, J. C., Carde, P., Ribrag, V., Fermé, C., & Lazarovici, J. (2018). Hodgkin lymphoma: Current and future therapeutic strategies. Bulletin du cancer
- Yeh, R., Dercle, L., Garg, I., Wang, Z. J., Hough, D. M., & Goenka, A. H. (2018). The Role of 18F-FDG PET/CT and PET/MRI in Pancreatic Ductal Adenocarcinoma. Abdominal radiology
- Aspeslagh, S., Matias, M., Palomar, V., Dercle, L., Lanoy, E., Soria, J. C., & Postel-Vinay, S. (2017). In the immuno-oncology era, is anti-PD-1 or anti-PD-L1 immunotherapy modifying the sensitivity to conventional cancer therapies?. European journal of cancer
- Huang, Q., Lu, L., Dercle, L., Lichtenstein, P., Li, Y., Yin, Q., Zong, M., Schwartz, L., & Zhao, B. (2018). Interobserver variability in tumor contouring affects the use of radiomics to predict mutational status. Journal of medical imaging
- Dercle, L., Lu, L., Lichtenstein, P., Yang, H., Wang, D., Zhu, J., Wu, F., Piessevaux, H., Schwartz, L. H., & Zhao, B. (2017). Impact of Variability in Portal Venous Phase Acquisition Timing in Tumor Density Measurement and Treatment Response Assessment: Metastatic Colorectal Cancer as a Paradigm. JCO clinical cancer informatics
- Dercle, L., Hartl, D., Rozenblum-Beddok, L., Mokrane, F. Z., Seban, R. D., Yeh, R., Bidault, F., & Ammari, S. (2018). Diagnostic and prognostic value of 18F-FDG PET, CT, and MRI in perineural spread of head and neck malignancies. European radiology
- Schernberg, A., Reuze, S., Orlhac, F., Buvat, I., Dercle, L., Sun, R., Limkin, E., Escande, A., Haie-Meder, C., Deutsch, E., Chargari, C., & Robert, C. (2018). A score combining baseline neutrophilia and primary tumor SUVpeak measured from FDG PET is associated with outcome in locally advanced cervical cancer. European journal of nuclear medicine and molecular imaging
- Sun, R., Limkin, E. J., Dercle, L., Reuzé, S., Zacharaki, E. I., Chargari, C., Schernberg, A., Dirand, A. S., Alexis, A., Paragios, N., Deutsch, É., Ferté, C., & Robert, C. (2017). Imagerie médicale computationnelle (radiomique) et potentiel en immuno-oncologie [Computational medical imaging (radiomics) and potential for immuno-oncology]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
- Sun, R., Champiat, S., Dercle, L., Aspeslagh, S., Castanon, E., Limkin, E. J., Baldini, C., Postel-Vinay, S., Hollebecque, A., Massard, C., Ammari, S., Deutsch, E., Soria, J. C., Marabelle, A., & Ferté, C. (2017). Baseline lymphopenia should not be used as exclusion criteria in early clinical trials investigating immune checkpoint blockers (PD-1/PD-L1 inhibitors). European journal of cancer
- Dercle, L., Ammari, S., Bateson, M., Durand, P. B., Haspinger, E., Massard, C., Jaudet, C., Varga, A., Deutsch, E., Soria, J. C., & Ferté, C. (2017). Limits of radiomic-based entropy as a surrogate of tumor heterogeneity: ROI-area, acquisition protocol and tissue site exert substantial influence. Scientific reports
- Dercle, L., Seban, R. D., Lazarovici, J., Schwartz, L. H., Houot, R., Ammari, S., Danu, A., Edeline, V., Marabelle, A., Ribrag, V., & Michot, J. M. (2018). 18F-FDG PET and CT Scans Detect New Imaging Patterns of Response and Progression in Patients with Hodgkin Lymphoma Treated by Anti-Programmed Death 1 Immune Checkpoint Inhibitor. Journal of nuclear medicine
- Reuzé, S., Orlhac, F., Chargari, C., Nioche, C., Limkin, E., Riet, F., Escande, A., Haie-Meder, C., Dercle, L., Gouy, S., Buvat, I., Deutsch, E., & Robert, C. (2017). Prediction of cervical cancer recurrence using textural features extracted from 18F-FDG PET images acquired with different scanners. Oncotarget
- Dierickx, L. O., Dercle, L., Chaltiel, L., Caselles, O., Brillouet, S., Zerdoud, S., & Courbon, F. (2019). Evaluation of 2 diuretic 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography imaging protocols for intrapelvic cancer. The quarterly journal of nuclear medicine and molecular imaging
- Limkin, E. J., Sun, R., Dercle, L., Zacharaki, E. I., Robert, C., Reuzé, S., Schernberg, A., Paragios, N., Deutsch, E., & Ferté, C. (2017). Promises and challenges for the implementation of computational medical imaging (radiomics) in oncology. Annals of oncology
- Mokrane, F. Z., Savall, F., Dercle, L., Crubezy, E., Telmon, N., Rousseau, H., & Dedouit, F. (2017). Technical note: A preliminary comparative study between classical and interventional radiological approaches for multi-phase post-mortem CT angiography.Forensic science international
- Champiat, S., Dercle, L., Ammari, S., Massard, C., Hollebecque, A., Postel-Vinay, S., Chaput, N., Eggermont, A., Marabelle, A., Soria, J. C., & Ferté, C. (2017). Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1. Clinical cancer research
- Terroir, M., Borget, I., Bidault, F., Ricard, M., Deschamps, F., Hartl, D., Tselikas, L., Dercle, L., Lumbroso, J., Baudin, E., Berdelou, A., Deandreis, D., Schlumberger, M., & Leboulleux, S. (2017). The intensity of 18FDG uptake does not predict tumor growth in patients with metastatic differentiated thyroid cancer. European journal of nuclear medicine and molecular imaging
- Michot, J. M., Mazeron, R., Dercle, L., Ammari, S., Canova, C., Marabelle, A., Rose, S., Rubin, E., Deutsch, E., Soria, J. C., Ribrag, V., & Levy, A. (2016). Abscopal effect in a Hodgkin lymphoma patient treated by an anti-programmed death 1 antibody.European journal of cancer
- Dercle, L., Ammari, S., Champiat, S., Massard, C., Ferté, C., Taihi, L., Seban, R. D., Aspeslagh, S., Mahjoubi, L., Kamsu-Kom, N., Robert, C., Marabelle, A., Schlumberger, M., Soria, J. C., & Postel-Vinay, S. (2016). Rapid and objective CT scan prognostic scoring identifies metastatic patients with long-term clinical benefit on anti-PD-1/-L1 therapy. European journal of cancer
- Dercle, L., Deandreis, D., Terroir, M., Leboulleux, S., Lumbroso, J., & Schlumberger, M. (2016). Evaluation of (124)I PET/CT and (124)I PET/MRI in the management of patients with differentiated thyroid cancer. European journal of nuclear medicine and molecular imaging
- Dercle, L., Ouali, M., Pascal, P., Giraudmaillet, T., Chisin, R., Lairez, O., Marachet, M. A., Rousseau, H., Bastié, D., Bouallègue, F. B., & Berry, I. (2015). Gated blood pool SPECT: The estimation of right ventricular volume and function is algorithm dependent in a clinical setting. Journal of nuclear cardiology
- Dercle, L., Chisin, R., Ammari, S., Gillebert, Q., Ouali, M., Jaudet, C., Delord, J. P., Dierickx, L., Zerdoud, S., Schlumberger, M., & Courbon, F. (2015). Nonsurgical giant cell tumour of the tendon sheath or of the diffuse type: are MRI or 18F-FDG PET/CT able to provide an accurate prediction of long-term outcome?. European journal of nuclear medicine and molecular imaging
- Dercle, L., Giraudmaillet, T., Pascal, P., Lairez, O., Chisin, R., Marachet, M. A., Ouali, M., Rousseau, H., Bastié, D., & Berry, I. (2014). Is TOMPOOL (gated blood-pool SPECT processing software) accurate to diagnose right and left ventricular dysfunction in a clinical setting?. Journal of nuclear cardiology
- Lairez, O., Cognet, T., Dercle, L., Méjean, S., Berry, M., Bastié, D., Richaud, R., Gautier, M., Fouilloux, A., Galinier, M., Carrié, D., Massabuau, P., & Berry, I. (2014). Prediction of all-cause mortality from gated-SPECT global myocardial wall thickening: comparison with ejection fraction and global longitudinal 2D-strain. Journal of nuclear cardiology
- Cognet, T., Vervueren, P. L., Dercle, L., Bastié, D., Richaud, R., Berry, M., Marchal, P., Gautier, M., Fouilloux, A., Galinier, M., Carrié, D., Massabuau, P., Berry, I., & Lairez, O. (2013). New concept of myocardial longitudinal strain reserve assessed by a dipyridamole infusion using 2D-strain echocardiography: the impact of diabetes and age, and the prognostic value. Cardiovascular diabetology